The Prognosis of Glyphosate herbicide intoxicated patients according to their salt types

Purpose: Glyphosate herbicide (GH) is a widely used and has been associated with significant mortality as poisoned cases increases. One of the reasons for high toxicity thought to be toxic effect its ingredient glyphosate. This study was designed determine differences in clinical course salt-type contained GH. Methods: retrospective conducted at single hospital between January 2013 December 2017. We enrolled GH-poisoned patients visited emergency department. According salt-type, were divided into 4 groups: isopropylamine (IPA), ammonium (Am), potassium (Po), mixed salts (Mi) groups. The demographics, laboratory variables, complications, their analyzed each salt-type. Addtionally, we subdivided survivor non-survivor groups investigating predictive factors mortality. Results: Total 348 follows: IPA 248, Am 41, Po 10, Mi 49 patients. There no difference demographic or underlying disease history, but systolic blood pressure (SBP) low group. ratio intentional ingestion higher Metabolic acidosis relatively lactate level presented As primary outcome, rates IPA, 26 (10.5%); Am, 2 (4.9%); Po, 1 (10%); Mi, (2%). statistically incidence complications. Additionally, age, SBP, pH, corrected QT (QTc) prolongation, respiratory failure requiring mechanical ventilation independent predictors regression analysis. Conclusion: statistical complications across GH-salt this study.